Melbourne's James Jordon and the Western Bulldogs' Laitham Vandermeer will serve as the medical substitutes for their respective sides in the AFL grand final.

There are no late changes for Saturday's premiership decider in Perth, where more than 60,000 fans are set to pack Optus Stadium.

Jordon and Vandermeer shape as future trivia answers given this is the first grand final since the AFL introduced the 23rd man.

One of the pair will receive a premiership medal regardless of whether they take the field.

The Bulldogs omitted Vandermeer and Ryan Gardner from the side that thrashed Port Adelaide in the preliminary final.

They make way for key defender Alex Keath (hamstring) and forward Cody Weightman (concussion), who have overcome their respective injuries.

Melbourne have stuck with the same side that crushed Geelong by 83 points in the preliminary final, meaning star defender Steven May has been named to play.

The All-Australian fullback was subbed out of the game against the Cats with a hamstring issue but the week off before the grand final has been crucial in proving his fitness.

Small forward Charlie Spargo was also under an injury cloud after rolling his ankle at training, but he has kept his spot.

Melbourne are gunning for their first premiership since 1964, while the Bulldogs are hoping to add a third flag to their successes in 1954 and 2016.